Edward and Alphonse Elric, two brothers gifted in the Art of Alchemy. Bound by the craft's Law of Conservation, and the principle of Equivalent Trade, The brothers find out just how much must be sacrificed in order to gain, when they attempt the forbidden art of Human Transmutation, and attempt to resurrect their dear mother.

Now, with Ed having lost an arm and a leg, and Al's entire body taken beyond The Gate, the brother's set out to find The Philosopher's Stone to try and set things right once again.